The Exploratory Handheld Optical Coherence Tomography Study in Wilson's Disease

Royal Surrey County Hospital NHS Foundation Trust

Status: Completed

Conditions: Wilson Disease

Treatments: Diagnostic Test: Diagnostic procedures

Study type: Interventional

Funder types: Other

Identifiers

NCT07046507

333382

Details and patient eligibility

About

This is an exploratory study using anterior segment optical coherence tomography (OCT) devices to measure copper in the eye. The investigators hope to use this to diagnosis kayser flesicher rings, an important diagnostic criteria in Wilson's disease.

Enrollment: 10 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Wilson patients with Kayser Fleischer rings on slit lamp examination and 5 patients without Kayser Fleischer rings on slit lamp examination

Exclusion criteria

• Those who do not have a confirmed diagnosis of Wilson's disease and no previous formal slit lamp examination will be excluded from recruitment.
• The investigators will also exclude those patients with known corneal disease, history of intraocular disease, haematological disease, pregnancy, and use of topical or intraocular medication.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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10 participants in 2 patient groups

Use of a fixed anterior segment OCT device to detect Kayser Fleischer ring

Active Comparator group

Treatment:

Diagnostic Test: Diagnostic procedures

Use of a handheld anterior segment OCT device to detect Kayser Fleischer rings

Active Comparator group

Treatment:

Diagnostic Test: Diagnostic procedures