The Expression Heparanase in Term and Preterm Placentas

Hillel Yaffe Medical Center

Status: Completed

Conditions: Preterm Birth

Treatments: Other: Placental analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03798964

HYMC-0119-18

Details and patient eligibility

About

Heparanase is an endo-β-glucuronidase that cleaves heparin-sulfate (HS) side chains of heparan sulfate proteoglycans, an integral constituent of the extra cellular matrix (ECM).

This study aims to investigate the association between heparanase expression in the human placenta and preterm birth (PTB) .

The investigators hypothesize that an abnormal placentation causes relative placental ischemia that induces higher rates of heparanase expression.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Singleton pregnancy

Exclusion criteria

• High-risk patients
• Multiple pregnancy
• Significant maternal illness
• Significant fetal anomaly

Trial design

20 participants in 3 patient groups

Elective term cesarean

Description:

Low-risk women undergoing elective term cesarean section

Treatment:

Other: Placental analysis

Term vaginal delivery

Description:

Low-risk women undergoing term vaginal delivery

Treatment:

Other: Placental analysis

Preterm vaginal delivery

Description:

Women undergoing preterm vaginal delivery

Treatment:

Other: Placental analysis