The Expression of Matrix Metalloproteinase 13, Tissue Inhibitor of Metalloproteinases 3, and Calcium-sensing Receptor in Human Trabecular Meshwork

Lv Yingjuan

Status: Completed

Conditions: Open-angle Glaucoma

Treatments: Procedure: trabeculectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT02638181

tjykdxykyy3

Details and patient eligibility

About

This study was to assess the distinct expression of matrix metalloproteinase 13,tissue inhibitor of metalloproteinases 3, and calcium-sensing receptor, in human trabecular meshwork between normal and glaucomatous eyes.The expressions of matrix metalloproteinase 13, tissue inhibitor of metalloproteinases 3 and calcium-sensing receptor in the trabecular meshwork tissues were examined by streptavidin-peroxidase immunohistochemical staining method and western blot, and histological changes of trabecular meshwork were studied by Hematoxylin and Eosin staining.

Enrollment: 60 patients

Sex: All

Ages: 50 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• intraocular pressure greater than 22 mmHg with two or more medications
• wide anterior chamber angle
• glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect
• visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion criteria

• the presence of any secondary form of glaucoma including exfoliation syndrome or a history of ocular trauma, etc

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

trabeculectomy

Experimental group

Treatment:

Procedure: trabeculectomy