The Expression of the Ionotropic Glutamate Receptors in Colon of IBS

Shandong University

Status: Unknown

Conditions: Irritable Bowel Syndrome

Treatments: Procedure: colonoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT02512146

2015SDU-QILU-G03

Details and patient eligibility

About

The study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Full description

Ionotropic glutamate receptors participate in pain in nervous system. In this study,participants will examine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.

Participants may futher study the mechanism using cell experiment.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients meeting IBS Rome III criteria. Asymptomatic individuals for health surveillance or patients for follow up after polypectomy.

Exclusion criteria

Patients with known cancers or abdominal surgery. Alarm symptoms such as anaemia, gastrointestinal bleeding or obstruction, marked weight loss, abdominal mass. Patients who are unwilling to sign or give the informed consent form. Patients with impaired cardiac, liver or renal function. Patients with coagulopathy. Patients with pregnancy or breastfeeding.

Trial design

80 participants in 2 patient groups

Irritable bowel syndrome

Description:

Patients meeting Rome III criteria of irritable bowel syndrome. Intervention: colonoscopy.

Treatment:

Procedure: colonoscopy

Normal controls

Description:

Asymptomatic individuals for health surveillance or patients for follow up after polypectomy. Intervention: colonoscopy.

Treatment:

Procedure: colonoscopy