The Expression Profile of New Complement Components in Childhood Lupus Nephritis

Assiut University

Status: Unknown

Conditions: Lupus Nephritis

Treatments: Combination Product: C4d evaluation in lupus nephritis in serum and renal tissue

Study type: Observational

Funder types: Other

Identifiers

NCT05082363

LNC4D

Details and patient eligibility

About

The aim of this study was to evaluate whether C4d is a better biomarker and examine whether C4d plasma levels correlate with treatment response and C4d kidney deposition in systemic lupus erythematosus (SLE) with lupus nephritis (LN).

Full description

Evaluation of C4d in lupus nephritis in children C4d level difference in children with systemic lupus with and without renal affection C4d level in lupus nephritis at activity and after remission Detection of C4d deposition in renal tissue relation to disease activity

Enrollment: 30 estimated patients

Sex: All

Ages: 1 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• This will include children and adolescents who fulfill the 2012 Systemic Lupus International Collaborating Clinics (SLICC)(10) classification criteria of SLE.

  • Inclusion Criteria:

    • Age younger than 18 years.
    • Active SLE with and without renal affection
    • Patients with biopsy proven LN according to ISN/RPS classification criteria of Lupus nephritis.

Exclusion criteria

• -Patients in remission.

Trial design

30 participants in 2 patient groups

systemic lupus wth renal affection

Description:

pt diagnosed with lupus nephritis

Treatment:

Combination Product: C4d evaluation in lupus nephritis in serum and renal tissue

systemic lupus without renal affection

Description:

pt diagnosed as systemic lupus without renal affection

Treatment:

Combination Product: C4d evaluation in lupus nephritis in serum and renal tissue