The Feasibility of a Physical Activity Intervention for Advanced Multiple Myeloma Patients

Dr. Nicole Culos-Reed

Status: Completed

Conditions: Advanced Cancer; Hematologic Neoplasms; Multiple Myeloma

Treatments: Behavioral: Physical Activity for Advanced Cancer Treatment (PAACT)

Study type: Interventional

Funder types: Other

Identifiers

NCT04303091

HREBA.CC-17-0058

Details and patient eligibility

About

Although physical activity (PA) is commonly used to manage symptoms and enhance quality of life (QOL) in cancer survivors, relatively little is known regarding the benefits in advanced multiple myeloma (MM). The primary aims of the Physical Activity in Advanced Cancer Treatment (PAACT) intervention were to examine (1) program feasibility and (2) potential impact on patient outcomes. It is hypothesized that an exercise intervention will be feasible and potentially impactful.

Full description

While the introduction of novel and more effective treatments has seen improved survival in multiple myeloma (MM), the aggressive nature of the disease and these corresponding agents can have a debilitating impact on quality of life (QOL). Exercise can help manage symptoms and enhance QOL in cancer survivors, however relatively little is known regarding the feasibility or benefits of exercise in MM. The purpose of this study was to examine the feasibility of a group- and home-based exercise intervention for individuals with advanced MM. In this single arm study, advanced MM patients (DS stage II-III) participated in a 12-week aerobic and resistance training intervention, with the option of palliative care consultation. Participants attended once weekly supervised group exercise classes and received individually tailored home exercise booklets. Validated measures of physical functioning and patient-reported outcomes, including QOL, fatigue, anxiety, depression, and self-compassion were obtained at baseline and 12-weeks (post-intervention). Optional semi-structured interviews were conducted halfway (week 6) and at the end of the intervention (week 12)

Enrollment: 19 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosed with advanced (Durie-Salmon stage II-III) multiple myeloma
• 18 years of age or older and given a survival prognosis greater than 6 months
• stable hemoglobin level of ≥80g/L as measured within 2 weeks of enrollment
• no active infections at the time of enrollment.

Exclusion criteria

• refusal of informed consent
• geographically inaccessible
• non-English speaking
• co-morbidities that interfere with participation (i.e., severe mobility issues or cognitive impairments)
• known or active history of substance abuse

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

Exercise group

Experimental group

Description:

Single-arm study. Participants enrolled engaged in a 12-week exercise program.

Treatment:

Behavioral: Physical Activity for Advanced Cancer Treatment (PAACT)