The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial

Third Affiliated Hospital of Zhengzhou University

Status and phase: Unknown; Phase 4

Conditions: Induced Abortion; Anesthesia

Treatments: Drug: propofol; Drug: pentazocine; Drug: Etomidate

Study type: Interventional

Funder types: Other

Identifiers

NCT02208596

20140729

Details and patient eligibility

About

To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.

Enrollment: 150 estimated patients

Sex: All

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 20 and 35 years
• American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ
• Singleton pregnancy and the gestational period is 6 to 8 weeks
• Expected operation duration is within 60 minutes
• The body weight should be within 15% around the standard weight
• Signed informed consent form

Exclusion criteria

• Serious cardiac, cerebral, liver, kidney, lung, endocrine disease
• Upper respiratory infections within 4 weeks
• Long use of hormone or history of adrenal suppression
• History of use of glucocorticoids, aprotinin or immunosuppressant
• Manifestation of immunodeficiency
• History of use of sedatives or opiates
• Needs of Neuromuscular blocker (except intubation)
• Allergy to trial drug or other contraindication
• Pregnant or breast-feeding women
• Attended other trial past 30 days

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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150 participants in 3 patient groups

Group A

Experimental group

Description:

In group A, propofol (1%) was mixed with etomidate in the ration of 1:1 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure.

Treatment:

Drug: propofol

Drug: Etomidate

Drug: pentazocine

Group B

Experimental group

Description:

In group B, propofol (1%) was mixed with etomidate in the ration of 7:5 (volume). The mixture will be injected continuously until the eyelash reflex disappears. During the operation, supplementary mixture will be administered if the patient has spontaneous movement that hampered the conduct of the procedure.

Treatment:

Drug: propofol

Drug: Etomidate

Drug: pentazocine

Group C

Experimental group

Description:

In group C, propofol (1%) will be injected continuously until the eyelash reflex disappears. During the operation, supplementary propofol will be administered if the patient has spontaneous movement that hampered the conduct of the procedure.

Treatment:

Drug: propofol

Drug: pentazocine