The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery

Kaohsiung Medical University

Status and phase

Completed

Phase 1

Conditions

Hemodialysis Complication

End Stage Renal Disease

Treatments

Device: Sevoflurane

Drug: Propofol

Study type

Interventional

Funder types

Other

Identifiers

NCT03311581

KMUHIRB-F(II)-20170080

Details and patient eligibility

About

Written informed consent must be obtained before any study specific procedures are undertaken. Informed consent will be obtained during pre-operative assessment.

Full description

The investigators will recruit 80 patients undergoing AV shunt surgery. All patients will receive general anesthesia and brachial plexus block. Patients will be randomly allocated into two groups. Study and control group received propofol target-controlled infusion (TCI) and inhaled anesthetics as anesthesia maintenance, respectively. Main outcomes will be assessed by perioperative blood pressure, heart rate, respiratory rate, end-tidal CO2, analgesics dosage, pain intensity and perioperative adverse events.

Enrollment

47 patients

Sex

All

Ages

20 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Uremic adult(over20-year-old)patients under going arteriovenous (AV) shunt surgery

Exclusion criteria

one of below systemic diseases; chronic pulmonary, cardiac diseases(such as COPD, asthma, acute myoischemia), hepatic co-mobility(such as liver cirrhosis), morbid obesity, alcoholism, allergy to propofol and inhaled anesthetics, the women who are pregnant or breastfeeding