The Features Behind the Beneficial Effects of Interval-walking (aIWS2)

Rigshospitalet

Status: Completed

Conditions: Diabetes Mellitus, Type 2

Treatments: Behavioral: IW3; Behavioral: Control; Behavioral: IW1

Study type: Interventional

Funder types: Other

Identifiers

NCT02257190

H-1-2014-060

Details and patient eligibility

About

A single bout of Interval-Walking (IW) exercise is superior to energy-expenditure and time-duration matched Continuous Walking (CW) exercise upon improving glycemic control. The reason IW is superior is unknown.

This study will look into whether it is the larger peak intensity during IW or if it is the alternating exercise pattern that is responsible for the larger improvements seen.

Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:

1. One hour of rest (Con)
2. One hour of classical interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW3)
3. One hour of fast alternating interval walking (repeated cycles of 1 min of fast and 1 min of slow walking; IW1).

After the interventions subjects will undergo a standardized mixed meal tolerance test, with consecutive measurements of blood glucose, insulin and c-peptide.

Enrollment: 12 patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 diabetes mellitus
• Body mass index > 18 but < 40 m2/kg
• Agreement to pause antidiabetic medication from 2 days before to after each trial

Exclusion criteria

• Pregnancy
• Smoking
• Use of exogenous insulin
• Contraindication to increased levels of physical activity
• Evidence of thyroid, liver, lung, heart or kidney disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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12 participants in 3 patient groups

Control (Con)

Experimental group

Description:

No exercise intervention.

Treatment:

Behavioral: Control

Interval Walking - 3 min intervals (IW3)

Experimental group

Description:

One hour of classical interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking.

Treatment:

Behavioral: IW3

Interval Walking - 1 min intervals (IW1)

Experimental group

Description:

One hour of fast alternating interval walking exercise (repeated cycles of 3 min of fast and 3 min of slow walking

Treatment:

Behavioral: IW1