The Foot in Your Nose Study: Links Between Nasal Staphylococcus Aureus Colonies and Diabetic Foot Lesion Infections

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Diabetic Foot; Staphylococcus Aureus

Treatments: Biological: Genetic profiling of bacterial cultures

Study type: Observational

Funder types: Other

Identifiers

NCT01212120

PHRC-I/2009/JPL-02

2009-A00849-48 (Other Identifier)

Details and patient eligibility

About

The presence of S aureus in the nasal passages of diabetic patients may be a risk factor for diabetic foot lesion infections. Our aim is to compare the genetic profiles of S aureus strains found in the noses and on the foot lesions of diabetic patients. The investigators are also studying the virulence of these strains, the prevalance of S aureus at either site, and whether or not the quantity of S aureus found in the nose affects the risk for infection in foot lesions. The investigators also use this study to test the sensitivity and specificity of the GeneXpert system.

Enrollment: 278 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 1 or 2 diabetic patients
• Patients consulting or hospitalized in the Diabetology departments of one of the participating centers
• Grade 2-4 ulcer on the foot or ankle (both primo and recurrent events are acceptable)

Exclusion criteria

• Patient refuses to participate
• Pregnant, parturient or breastfeeding women
• Patient does not have diabetic foot or arteritic
• Diabetic ulcer is located elsewhere than the foot or ankle
• The ulcer is non-swabbable
• Patient does not have social-security coverage
• Patient is under any type of guardianship

Trial design

278 participants in 1 patient group

All patients

Description:

All patients

Treatment:

Biological: Genetic profiling of bacterial cultures