The Frequency of Polycystic Ovary Syndrome Among Young Reproductive Females Presenting With Hyperandrogenism: a Mixed Cohort Study

Woman's Health University Hospital, Egypt

Status

Enrolling

Conditions

PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries

Treatments

Diagnostic Test: clinical, biophysical and biochemical assessment of young females with clinical hyperandrogenism

Study type

Observational

Funder types

Other

Identifiers

NCT05734287

123456

Details and patient eligibility

About

This mixed cohort study will test the frequency of PCOS among young females presenting with one of the clinical hyperandrogenism criteria: acne, hirsutism and/or hair loss. Diagnosis will be based on the recent PCOS clinical, biochemical and biophysical criteria recently published " International evidence-based guideline for the assessment and management of polycystic ovary syndrome (PCOS) 2018".

Full description

Irregular menstrual cycles are defined as:

normal in the first year post menarche as part of the pubertal transition
> 1 to < 3 years post menarche: < 21 or > 45 days
> 3 years post menarche to perimenopause: < 21 or > 35 days or < 8 cycles per year
> 1 year post menarche > 90 days for any one cycle
Primary amenorrhea by age 15 or > 3 years post thelarche (breast development) When irregular menstrual cycles are present a diagnosis of PCOS should be considered.

Biochemical hyperandrogenism: Calculated free testosterone, free androgen index or calculated bioavailable testosterone. Androstenedione and dehydroepiandrosterone sulfate (DHEAS) could be considered if total or free testosterone are not elevated. (ELIZA or radioimmunoassay).

A comprehensive history and physical examination should be completed for symptoms and signs of clinical hyperandrogenism, including acne, alopecia and hirsutism and, in adolescents, severe acne and hirsutism using the modified Ferriman Gallwey score (mFG). Transvaginal (transabdominal if virgins) Ultrasound and polycystic ovarian morphology: Ultrasound should not be used for the diagnosis of PCOS in those with a gynaecological age of < 8 years (< 8 years after menarche), due to the high incidence of multi-follicular ovaries in this life stage. Transabdominal ultrasound reporting is best focused on ovarian volume with a threshold of ≥ 10ml. Endovaginal U/S should show a follicle number per ovary of ≥ 20 and/or an ovarian volume ≥ 10ml, ensuring no corpora lutea, cysts or dominant follicles are present.

Enrollment

260 estimated patients

Sex

Female

Ages

15 to 35 years old

Volunteers

No Healthy Volunteers

Inclusion criteria