The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study

McGill University

Status: Unknown

Conditions: Dilated Cardiomyopathy (DCM)

Treatments: Other: blood test

Study type: Observational

Funder types: Other

Identifiers

NCT00523653

BMB 07-004

Details and patient eligibility

About

Dilated cardiomyopathy (DCM) affects about 200,000 Canadians. Eighty percent of these cases are of unclear cause, often occuring in families. We believe that mutations in specific already-identified genes contribute to DCM in Quebec and that certain mutations may account for a significant proportion of cases due to the well-documented "founder effect". Two hundred patients with DCM followed in our Heart Function Clinic will be approached for one blood sample at their routine clinic visit to test this hypothesis. The samples will be tested in the Laboratory of Cardiovascular Genetics at the Royal Victoria Hospital.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Followed at MUHC Heart Function Centre
• Documented EF of less than or equal to 35% and an enlarged heart with a left ventricular end-diastolic size of greater than 6 cm.
• Patient's written consent

Exclusion criteria

• Patients with a known underlying condition that results in a weakened and enlarged heart
• Patients unable to read and understand the consent form
• Patients who do not wish to participate