The Gut-lung Axis in Chronic Obstructive Pulmonary Disease

Peking University

Status: Unknown

Conditions: Metabolism; Pulmonary Disease, Chronic Obstructive; Immunity, Mucosal; Microbiota

Study type: Observational

Funder types: Other

Identifiers

NCT03236480

2109901

2016YFC0903800

Details and patient eligibility

About

Patients with chronic obstructive pulmonary disease (COPD) are 2-3 times more likely to occur together with chronic gastrointestinal tract (GIT) diseases, such as inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS). Similarly, despite many patients have no history of acute or chronic respiratory disease, up to 50% of IBD patients and 33% of IBS patients have pulmonary involvement, such as inflammation or impaired lung function. Increasing evidence indicated chronic gut and lung disease share key conceptual features with the disorder and dysregulation of the microbial ecosystem. However, the underlying mechanisms are not well understood.

Our study is aimed to elucidate the intimate relationship between the gastrointestinal tract and respiratory tract, and uncover the mechanisms by which the gut microbiota affects the immune responses in the lungs, and vice versa.

Enrollment: 100 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• admitted to hospital with an exacerbation of COPD;
• with no history of probiotics taken;
• the duration of antibiotics treatment before enrollment should be less than 72 hours.

Exclusion criteria

• being immunocompromised, including history of glucocorticoid taken for more than 1 month, history of immunosuppressive therapy, history of human immunodeficiency virus (HIV) infection, solid tumor or hematological malignancy;
• history of long-term nursing home stays;
• history of recently hospitalized (<90 days).

Trial design

100 participants in 2 patient groups

COPD

Description:

Patients who admitted to Peking Universtiy People's Hospital and Ningde City Hospital between January 2017 and January 2019 with AECOPD will be enrolled

healthy control

Description:

People aged over 40, without any chronic respiratory disease or acute respiratory infections in the last 2 weeks, and be willing to participate in the study