The Gut Microbiota and Delirium in the ICU (GuMDel-ICU)

Herlev Hospital

Status: Unknown

Conditions: Microbial Colonization; Delirium of Mixed Origin

Treatments: Diagnostic Test: Metagenomic analysis of gut microbiota

Study type: Observational

Funder types: Other

Identifiers

NCT03328377

GuMDel-ICU

Details and patient eligibility

About

To investigate whether the composition of the gut microbiota is different in patients that develop delirium during critical illness as compared to patients who do not.

Full description

We plan to include an equal number of patients admitted to the ICU, that either do or don't develop delirium during their course of critical illness. Samples of feces/rectal swaps will be taken at admission and again either when the patients become CAM-ICU positive, alternatively after 5 days admssion/at discharge in patients that remain CAM-ICU negative.

Samples are then sent to analyses for purification of bacterial DNA and metagenomic analysis.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Admission to the ICU, Disability to make informed consent due to critical illness -

Exclusion Criteria: Dementia. Delirium diagnosed prior to the ICU admission on the non-ICU floors. Coma. Indication for deep sedation (-4/-5).