The Hasselt APPendicitis Immunology and Environmental Cohort STudy (HAPPIEST)

Hasselt University

Status: Unknown

Conditions: Appendicitis

Study type: Observational

Funder types: Other

Identifiers

NCT02391675

12.17/infect12.03

Details and patient eligibility

About

The Hasselt Appendicitis Immunology and Environmental Study (HAPPIEST) aims at characterizing factors that influence the development and severity of acute appendicitis. In a cohort of 300 patients and 300 controls, environmental factors as well as genetic make-up of the innate immune system, focusing mainly on pattern recognition, will be analyzed in order to gain insight in their relative importance in the pathology of appendicitis. Furthermore, populations of micro-organisms present in the gut of patients will be characterized, and the interaction between relevant micro-organisms and the innate immune system will be analyzed.

Enrollment: 308 patients

Sex: All

Ages: 5 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Acute appendicitis
• Appendectomy within 7 days after onset of symptoms
• Signed informed consent

Exclusion criteria

• Appendectomy 7 days or more after onset of symptoms
• Participation in any clinical investigational drug study within 4 weeks of screening
• Severe, life-threatening disease with a life expectancy of less than 2 months.

Trial design

308 participants in 1 patient group

Appendicitis patients

Description:

Patients presenting with acute appendicitis