The 'Hidden' Biological Impact of Vitamin D Deficiency: a Biomarker Study; Part 2

The Hong Kong Polytechnic University

Status and phase: Completed; Phase 2

Conditions: Vitamin D Deficiency

Treatments: Dietary Supplement: Vitamin D

Study type: Interventional

Funder types: Other

Identifiers

NCT02451787

Vit D Study part 2 v.1

Details and patient eligibility

About

The investigators major aims are to: determine the vitamin D status of a group of young, apparently healthy adults in Hong Kong; examine inter-relationships between vitamin D status and biomarkers of DNA damage and repair, oxidative stress, inflammation and endothelial health; and, in part 2 of the study, investigate effects of improvement in vitamin D status on these biomarkers and other measures of well-being in those young adults shown to be deficient in vitamin D.

Full description

In this part 2 of the study the investigators will investigate the effect of vitamin D supplementation on biomarkers of these 'hidden' changes in apparently healthy young adults. The investigators will also explore the effect of improvement in vitamin D status in young apparently healthy adults in regard to muscular strength and response time, glucose control, a hormone that is linked to vitamin D (parathyroid hormone (PTH) ) and mood.

Enrollment: 27 patients

Sex: All

Ages: 18 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• apparently healthy, non-smokers
• non-obese
• found (in part1) to have low vitamin D status

Exclusion criteria

• chronic illness
• serious illness requiring medical treatment in previous 6 months
• pregnancy
• on regular medication or taking supplements on a regular basis

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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27 participants in 2 patient groups, including a placebo group

Active

Experimental group

Description:

vitamin D supplementation group (2500 IU day for 3 months)

Treatment:

Dietary Supplement: Vitamin D

Control

Placebo Comparator group

Description:

no vitamin D supplementation

Treatment:

Dietary Supplement: Vitamin D