The Impact of Anesthesia on High- Grade Glioma Patients

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Capital Medical University

Status

Unknown

Conditions

Anesthesia, Outcome, High-grade Glioma

Treatments

Other: IV Anesthesia
Other: IH anesthesia

Study type

Interventional

Funder types

Other

Identifiers

NCT02756312
ChiECRCT-20200049

Details and patient eligibility

About

Although bench data and retrospective studies have provided a promising picture of the possible influence of anesthetic technique on the risk of tumor progression and patients mortality, current evidence from RCTs is inadequate to show whether the type of anesthetics might influence tumor progression and patient survival.There are many thousands of patients with a cancer diagnosis undergoing surgery every year, and in the context of biological plausibility, it should lead to the urgent undertaking of RCTs to further evaluate the association between the anesthetic management and patient outcome.

Full description

Although bench data and retrospective studies have provided a promising picture of the possible influence of anesthetic technique on the risk of tumor progression and patient mortality, current evidence from RCTs is inadequate to show whether the type of anesthetics might influence the outcome of the patients.There are many thousands of patients with a cancer diagnosis undergoing surgery every year, and in the context of biological plausibility, it should lead to the urgent undertaking of RCTs to further evaluate the association between the anesthetic management and patient outcome.

Enrollment

196 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

1)Magnetic radiology imaging diagnosis of supratentorial high-grade glioma; 2) Patients undergoing tumor resection under selective general anesthesia; 3) Age 18-80 years old; 4) Preoperative KPS < 80; 5) With written informed consent by patients or their relatives.

Exclusion criteria

1) History of other operations before; 2) Patients with recurrence and metastasis of gliomas or with malignant tumors of other organs; 3) Emergency operation; 4) Critical condition (ASA grade ≥ V before operation, Appendix 1, Severe liver and kidney dysfunction; 5) Patients with mental illness, severe dementia, language disorder, coma, and end-stage disease, etc.; 6) Pregnant or breastfeeding women; 7) Allergic to study drugs;8) Patients who need electrophysiological monitoring during operation. 9) Patients receiving reoperation with different anesthesia methods will be removed and the patients with the same anesthesia method will be continued to observe; 10) Postoperative pathological result is not high-grade glioma.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

196 participants in 2 patient groups

Intravenous anesthesia
Other group
Description:
Patients will receive total intravenous anesthesia undergoing brain tumor resection.
Treatment:
Other: IV Anesthesia
Inhalation anesthesia
Other group
Description:
Patients will receive volatile inhalational anesthesia undergoing brain tumor resection.
Treatment:
Other: IH anesthesia

Trial contacts and locations

1

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Central trial contact

Yuming Peng, M.D., Ph.D.

Data sourced from clinicaltrials.gov

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