The Impact of Change of Thyroid Antibodies on Hormone Level and Disease Burden in Patients With Hashimoto's Thyroiditis (Anti-TPO/TG)

Sherihan AboElyazed Mohamed Khalil

Status: Completed

Conditions: Mediterranean Diet; Hashimoto Thyroiditis

Treatments: Dietary Supplement: Dietary modification

Study type: Interventional

Funder types: Other

Identifiers

NCT07048821

MS 232/2023

Details and patient eligibility

About

Hashimoto's thyroiditis (HT) is an autoimmune disease affecting the thyroid gland and is one of the most common causes of hypothyroidism. Eating habits may affect the risk of several inflammatory and immune diseases, such as HT. The current knowledge of the diet in HT is insufficient. The Mediterranean diet (MD) is an anti-inflammatory diet characterized by frequent consumption of olive oil, unrefined cereals, fresh or dried fruit and vegetables, moderate amounts of fish, dairy, and meat, and many condiments and spices. It is rich in nutrients and bioactives, which have the potential to offer anti-inflammatory aspects.

Full description

The investigators aimed to assess the impact of the Mediterranean diet on patients with Hashimoto thyroiditis using the following outcomes:

Primary outcomes: Anti-TPO antibodies, Anti-Thyroglobulin antibodies, TSH, T3, T4 Secondary outcomes: BMI, Lipid profile, Symptoms of hypothyroidism

Enrollment: 40 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with symptoms of hypothyroidism (hypothyroid/euthyroid)
• Positive anti-thyroid antibodies (anti-TPO/anti-TG).

Exclusion criteria

• Pregnant or lactating females
• Age below 20 years and above 50 years
• presence of any other medical disorder

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

patients with hashimoto thyroiditis

Experimental group

Description:

The investigators advised patients to follow a modified Mediterranean diet plan with a reduction in goitrogenic foods for 12 weeks.

Treatment:

Dietary Supplement: Dietary modification