The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement

Negovsky Reanimatology Research Institute

Status: Enrolling

Conditions: Gonarthrosis; Osteo Arthritis Knee

Treatments: Procedure: Single-shot adductor canal block; Procedure: Continuous femoral nerve block

Study type: Interventional

Funder types: Other

Identifiers

NCT05487053

AdORe - ACB

Details and patient eligibility

About

Total knee replacement (TKR) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. A well-known problem of TKR is a severe postoperative pain syndrome, which is observed in more than 50% of patients.

Femoral nerve block (FNB) is the "gold standard" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. At the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling.

Adductor canal block (ACB) provides adequate analgesia comparable to femoral nerve block. Moreover, ACB doesn't affect the motor function of the quadriceps femoris muscle.

The possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.

Enrollment: 220 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18
• Planned primary total knee replacement
• Planned neuraxial anesthesia
• Written informed consent

Exclusion criteria

• Urgent surgery
• Planned revision total knee replacement
• Known allergic reaction to anesthetics
• Confirmed localized infection at the puncture sites
• Confirmed localized tumor at the puncture sites
• Peripheral neuropathy of the lower extremities
• Parkinson's disease
• Previously enrolled in this trial

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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220 participants in 2 patient groups

Single-shot adductor canal block

Experimental group

Treatment:

Procedure: Single-shot adductor canal block

Continuous femoral nerve block

Active Comparator group

Treatment:

Procedure: Continuous femoral nerve block