The Impact of Continuous Renal Replacement Therapy on the Outcomes of Burn Patients With Early Phase of Sepsis (CRRT)

Army Medical University

Status

Unknown

Conditions

Burns

Sepsis

Treatments

Procedure: Continuous Renal Replacement Therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT01501097

SWHCBS01

Details and patient eligibility

About

The purpose of this study is to determine if early application of CRRT will result in an improvement of clinical outcomes of burn patients during the early phase of sepsis

Full description

The impact of Continuous Renal Replacement Therapy (CRRT) on the outcomes of patients with sepsis is controversial, and there is no consensus for the timing and dose of CRRT may improve the outcomes. The purpose of this prospective randomized study is to assess the effect of different CRRT intensity (25ml/kg/h or 50ml/kg/h) on the outcomes of burn patients with early phase of sepsis

Enrollment

60 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients with documented sepsis
clinically identified focus of infection associated with at least 2 SIRS -criteria and one or more sepsis-induced organ failures within the 24 hours -prior to inclusion
age 18 to 70 years
severe burned patients with 50% < TBSA < 85%

Exclusion criteria

cirrhosis child class C
too high APACHE II & SOFA score at admission
age over 70 years
were presence of a malignant tumor, chronic renal insufficiency (serum creatinine > 133 µmol/L), moribund state, receiving immunosuppressive therapy or receiving any kind of renal replacement therapy before randomization