The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Elderly (TAHOC)

Central Hospital, Nancy, France

Status: Completed

Conditions: Hypertension; Aged, 80 and Over; Dementia; Neurocognitive Disorders

Treatments: Drug: Antihypertensive Agents

Study type: Observational

Funder types: Other

Identifiers

NCT05845736

2023PI017

Details and patient eligibility

About

Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension. However, studies have shown that in aging adults, high blood pressure helps prevent against cognitive decline, and low blood pressure on antihypertensive drugs could accelerate it. This study aims at investigating if pharmacological treatment of hypertension in the very elderly is influenced by presence and severity of neurocognitive disorders. Our research hypothesis is that the drug management of hypertension in patients 80 years of age or older more is all the less aggressive as the neurocognitive disorders are advanced.

Enrollment: 353 patients

Sex: All

Ages: 80+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• to be 80 years of age
• with history of hypertension and/or on hypertensive drug(s)

Exclusion criteria

• legal protection measure.

Trial design

353 participants in 4 patient groups

control group

Description:

absence of neurocognitive disorder (ND), Mini-Mental State Examination (MMSE) from 27 to 30 inclusive

Treatment:

Drug: Antihypertensive Agents

mild neurocognitive disorder

Description:

MMSE from 21 to 26 inclusive

Treatment:

Drug: Antihypertensive Agents

moderate neurocognitive disorder

Description:

MMSE from 11 to 20 inclusive

Treatment:

Drug: Antihypertensive Agents

severe neurocognitive disorder

Description:

MMSE less than or equal to 10

Treatment:

Drug: Antihypertensive Agents