The Impact of E-liquid Nicotine Content on Reinforcement in Current Smokers

Wake Forest University (WFU)

Status

Withdrawn

Conditions

Tobacco Use

Treatments

Behavioral: E-liquid sampling and preference assessment

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT03186911

1U54DA031659-01 (U.S. NIH Grant/Contract)

U54 DA031659-06 Pilot

Details and patient eligibility

About

Participants will complete a phone screen and then one laboratory session. After completing in-person screening assessments, eligible participants will complete additional questionnaires. Participants will then choose an e-liquid flavor to use for the rest of the session. Participants will then sample two e-liquids that vary in nicotine content from little or no nicotine to a moderate level of nicotine, and questionnaires evaluating the subjective effects of each one. Participants will then complete a preference assessment where they choose between the two e-liquids. Participants will be blind to the nicotine contents.

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

At least 18 years old
Daily cigarette smoking
Have tried vaping devices on a minimum of one lifetime occasion

Exclusion criteria

Unwilling to use a vaping device during the session
Break alcohol level > 0.01 (g/dL)
Pregnant, trying to become pregnant, or breastfeeding
Systolic BP greater than or equal to 160 mm/Hg or below 90 mm/Hg
Diastolic BP greater than or equal to 100 mm/Hg or below 50 mm/Hg
Heart rate greater than or equal to 105 bpm or lower than 45 bpm
A current upper respiratory infection, recent cardiac event (in the last year), Buerger disease, irregular heartbeat or arrhythmia within the last year, previous allergic or adverse reaction to nicotine