The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females

University of Exeter

Status: Completed

Conditions: Healthy

Treatments: Other: Oral Placebo; Other: Oral Protein; Other: Enteral Protein

Study type: Interventional

Funder types: Other

Identifiers

NCT03571425

180509/B/03

Details and patient eligibility

About

The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.

Full description

Thirty healthy, young volunteers will receive a stable isotope tracer infusion (8.5h) combined with repeated blood and muscle sampling, in order to measure muscle protein synthesis rate in the postabsorptive state, and following oral placebo ingestion (n=10), oral protein ingestion (n=10), or enteral protein administration (n=10).

Enrollment: 30 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-40 years of age
• Body mass index between 18.5 and 30

Exclusion criteria

• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
• Any diagnosed cardiovascular disease
• Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements)
• Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism). This excludes oral contraceptives and contraceptive devices.
• A personal or family history of epilepsy, seizures or schizophrenia.
• Presence of an ulcer in the stomach or gut and/or strong history of indigestion
• Known pre-existing liver disease/condition
• Any known disorders in muscle metabolism
• Regular use of nutritional supplements
• Allergy to lidocaine
• Allergy to milk
• Current paracetamol use (i.e. use of paracetamol more than once a week)
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 3 patient groups, including a placebo group

Oral Placebo

Placebo Comparator group

Description:

Placebo drink

Treatment:

Other: Oral Placebo

Oral Protein

Active Comparator group

Description:

Protein drink, ingested orally

Treatment:

Other: Oral Protein

Enteral Protein

Active Comparator group

Description:

Protein drink, administered via enteral tube

Treatment:

Other: Enteral Protein