The Impact of ERA Switching on Risk Stratification in Pulmonary Arterial Hypertension (ACTION)

University of Sao Paulo General Hospital

Status: Enrolling

Conditions: Pulmonary Arterial Hypertension (PAH); Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH); Pulmonary Arterial Hypertension

Treatments: Other: Switch from Ambrisentan to Bosentan; Drug: Maintenance of Ambrisentan Therapy

Study type: Observational

Funder types: Other

Identifiers

NCT07013149

SGP26691

Details and patient eligibility

About

Pulmonary arterial hypertension (PAH) is a rare, progressive, and potentially life-threatening disease characterized by pulmonary vascular remodeling, increased pulmonary vascular resistance, and right ventricular dysfunction. The endothelin pathway plays a central role in its pathophysiology and is targeted by endothelin receptor antagonists (ERAs), including ambrisentan and bosentan.

Ambrisentan is a selective ETA receptor antagonist, whereas bosentan blocks both ETA and ETB receptors. Although transitions between ERAs occur in clinical practice, evidence regarding the clinical impact of switching from ambrisentan to bosentan remains limited.

ACTION is a retrospective, observational, single-center cohort study evaluating adult patients with pulmonary arterial hypertension (World Health Organization Group 1) and/or chronic thromboembolic pulmonary hypertension (World Health Organization Group 4) confirmed by right heart catheterization. Patients who switched from ambrisentan to bosentan because of a national ambrisentan shortage will be compared with clinically similar patients who remained on ambrisentan.

Clinical, functional, and laboratory data recorded at baseline and at 3 to 6 months of follow-up will be assessed. The primary outcome is the proportion of patients with worsening risk stratification after switching from ambrisentan to bosentan compared with patients who continued ambrisentan. Risk will be evaluated using the COMPERA 2.0 and REVEAL Lite 2 assessment tools.

Secondary outcomes include changes in World Health Organization/New York Heart Association functional class, 6-minute walk distance, BNP levels, individual risk-assessment components, hepatic enzymes, hemoglobin levels, and clinically relevant events such as hospitalization, emergency department visits, initiation of supplemental oxygen, and right heart failure decompensation.

Full description

Pulmonary arterial hypertension (PAH) is a progressive and potentially life-threatening condition characterized by pulmonary vascular remodeling, increased pulmonary vascular resistance, right ventricular dysfunction, and premature mortality. Chronic thromboembolic pulmonary hypertension (CTEPH) is a distinct form of precapillary pulmonary hypertension classified as World Health Organization Group 4. In selected patients with PAH or inoperable or residual CTEPH, therapies targeting the endothelin pathway may be used as part of clinical management.

Endothelin-1 contributes to pulmonary vasoconstriction and vascular remodeling through ETA and ETB receptors. Endothelin receptor antagonists are an established component of PAH treatment. Ambrisentan selectively antagonizes the ETA receptor and is administered once daily, whereas bosentan is a dual ETA/ETB receptor antagonist that requires regular monitoring because of its potential hepatic and hematologic adverse effects.

Transitions between medications within the ERA class may occur because of adverse events, clinical considerations, patient-related factors, or medication availability. However, evidence regarding the clinical consequences of switching from ambrisentan to bosentan is limited, particularly when the transition is imposed by an external disruption in medication supply rather than planned as an elective therapeutic strategy.

The ACTION study is a retrospective, observational, single-center cohort study designed to assess the real-world clinical impact of switching from ambrisentan to bosentan. The study includes adults aged 18 years or older with PAH or CTEPH confirmed by right heart catheterization. Two exposure groups will be evaluated: patients who transitioned from ambrisentan 10 mg to bosentan 125 mg following a national shortage of ambrisentan and patients with a similar clinical profile who remained on ambrisentan.

Baseline data will correspond to the clinical assessment performed at or near the time of the medication transition in the switch group and to a comparable reference assessment in the maintenance group. Follow-up data recorded 3 to 6 months later will be used to evaluate changes within each group and differences between groups.

The primary outcome is worsening of risk stratification after the medication transition, comparing patients who switched to bosentan with patients who remained on ambrisentan. Risk will be assessed using COMPERA 2.0 and REVEAL Lite 2. Analyses will include between-group comparisons and within-group comparisons of risk categories and their individual components.

Secondary outcomes include changes in World Health Organization/New York Heart Association functional class, 6-minute walk distance, BNP levels, hepatic transaminases, and hemoglobin. The study will also evaluate clinically relevant events, including hospitalization, emergency department visits, initiation of supplemental oxygen, and decompensation of right heart failure.

By including a contemporaneous maintenance group, the ACTION study seeks to distinguish changes potentially associated with the medication switch from changes related to the natural course of pulmonary hypertension and routine clinical follow-up. The results may provide clinically relevant evidence regarding the safety and consequences of non-elective ERA substitution in real-world care.

Enrollment: 183 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years
• Confirmed diagnosis of pulmonary arterial hypertension (PAH) by right heart catheterization
• Documented therapeutic switch from ambrisentan (10 mg once daily) to bosentan (125 mg twice daily) within the previous 6 months for the switch group
• Treatment with ambrisentan for at least 6 months without switching to bosentan for the maintenance group

Exclusion criteria

• History of severe hepatic impairment
• Incomplete clinical or laboratory records that prevent risk score calculation
• Inability to attend clinical follow-up between 3 and 6 months after medication switch

Trial design

183 participants in 2 patient groups

Patients who switched from Ambrisentan to Bosentan

Description:

This cohort includes adult patients (≥18 years) with a confirmed diagnosis of pulmonary arterial hypertension (PAH) by right heart catheterization who underwent a therapeutic transition from ambrisentan 10 mg once daily to bosentan 125 mg twice daily within the past 6 months. Patients are followed during routine clinical care and assessed between 3 and 6 months after the switch to evaluate changes in risk stratification scores (COMPERA 2.0 and REVEAL Lite 2.0), functional capacity, laboratory parameters, and adverse events. No investigational drug or additional intervention is administered beyond standard care.

Treatment:

Other: Switch from Ambrisentan to Bosentan

Ambrisentan Maintenance Group

Description:

This cohort includes adult patients (≥18 years) with a confirmed diagnosis of pulmonary arterial hypertension (PAH) by right heart catheterization who remained on ambrisentan 10 mg once daily and did not undergo a therapeutic switch to bosentan. Clinical, functional, and laboratory data recorded at baseline are compared with data recorded between 3 and 6 months later to evaluate changes in risk stratification scores, functional capacity, laboratory parameters, and clinical events. No investigational drug or additional intervention was administered beyond standard care.

Treatment:

Drug: Maintenance of Ambrisentan Therapy