The Impact of Genicular Nerves Chemical Neurolysis on the Quality of Life of Patients with Advanced Knee Osteoarthritis.

Poznan University of Medical Sciences (PUMS)

Status and phase: Completed; Phase 4

Conditions: Osteoarthritis; Osteo Arthritis Knee

Treatments: Drug: 0.9% Sodium chloride; Drug: 95% ethanol

Study type: Interventional

Funder types: Other

Identifiers

NCT06087601

6/2023

Details and patient eligibility

About

Genicular nerves chemical neurolysis in advanced osteoarthritis of the knee joint.

Full description

The study aims to assess the safety and effectiveness of regional pain treatment methods and their impact on the quality of life of patients with advanced osteoarthritis of the knee joint.

Enrollment: 100 patients

Sex: All

Ages: 18 to 110 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of the Pain Treatment Clinic of the Transfiguration of Jesus Clinical Hospital of the Medical University of Poznań will be qualified for the study
• patients with gonarthrosis who failed to achieve satisfactory pain control (NRS>3) despite the use of NSAIDs, Paracetamol, and co-analgesics
• Age of patients: from 18 to 110 years of age.
• Caucasian patients can give informed, complete, written consent.

Exclusion criteria

• suspected or diagnosed opioid dependence syndrome
• active cancer
• dementia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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100 participants in 2 patient groups

Sham blocks

Active Comparator group

Description:

US-guided Bilateral genicular nerve block with 0,9% NaCl

Treatment:

Drug: 0.9% Sodium chloride

Genicular nerve neurolysis

Active Comparator group

Description:

US-guided Bilateral genicular nerve neurolysis with 0,5ml 95% ethanol

Treatment:

Drug: 95% ethanol