The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.

Uppsala University Hospital

Status: Completed

Conditions: Colorectal Cancer, Peritoneal Carcinomatosis, Anastomosis Insufficiency

Treatments: Procedure: Colectomy, CRS+HIPEC

Study type: Observational

Funder types: Other

Identifiers

NCT04252560

2019-04562

Details and patient eligibility

About

The role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. This is a pilot study.

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria Colorectal group

• adenocarcinom in colon or rektum
• curative operation planed
• direct anastomose plan
• elective surgery

Inclusion Criteria HIPEC group :

• All patients with appendix, colon or rectal cancer accepted for CRS+HIPEC

Exclusion Criteria:

• Ongoing antibiotics treatment
• antibiotics treatment in the last 6 months
• acute surgery
• palliative surgery
• Ulcerös colitis or Crohns disease
• Prior colectomy
• Small intestine stoma before the operation
• neoadjuvant treatment
• Colon preparation

Trial design

45 participants in 2 patient groups

Colorectal

Description:

30 patients operated for colorectal cancer

Treatment:

Procedure: Colectomy, CRS+HIPEC

HIPEC

Description:

15 patients operated with CRS+HIPEC for peritoneal carcinomatosis

Treatment:

Procedure: Colectomy, CRS+HIPEC