The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response

Prof. Yoram Epstein

Status: Terminated

Conditions: "Exposure to Heat"

Treatments: Other: exposure to heat

Study type: Interventional

Funder types: Other

Identifiers

NCT00808925

SHEBA-08-5524-YE-CTIL

Details and patient eligibility

About

There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain heat stress - "heat intolerance" is also attributed to over-expression of inflammatory cytokines. Acclimation to heat improves human sustainability to heat and is a leading protective factor against heat stroke. The investigators hypothesize that the lower stress encountered during the process of acclimation to heat will be reflected by an over-ride in the expression of anti-inflammatory over the pro-inflammatory cytokines. This, in turn will attenuate the pathological cascade leading to heat stroke.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age:18-25
• medically screened (healthy)

Exclusion criteria

• BMI over 22 kg/m2
• systolic blood pressure over 120 mmHg
• any febrile illness during the last week preceding the study
• any skin disease
• diabetes
• any heart conditions.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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10 participants in 1 patient group

research arm

Experimental group

Treatment:

Other: exposure to heat