The Impact of Hepatic Steatosis on Survival After Pancreaticoduodenectomy

Wei-Hsun Lu

Status: Completed

Conditions: Nonalcoholic Fatty Liver Disease After Pancreaticoduodenectomy

Treatments: Procedure: Pancreaticoduodenectomy

Study type: Observational

Funder types: Other

Identifiers

NCT07182136

ChengKungUniversityTainan

Details and patient eligibility

About

We will use simple summaries, educational handouts, and discussions with doctors and nurses to explain this study. The study looks at patients with early-stage pancreatic cancer who undergo pancreaticoduodenectomy (Whipple surgery). We found that some patients develop fatty liver (non-alcoholic fatty liver disease, NAFLD) within six months after surgery, which can affect nutrition, blood sugar control, and long-term survival.

To help patients and families understand, we will:

1. Provide clear written information sheets about the purpose of the study and its findings.
2. Use diagrams or plain-language explanations of terms like "pancreatic exocrine function" and "fatty liver."
3. Share results with healthcare providers so they can guide patients in nutrition, enzyme replacement, diabetes monitoring, and follow-up care.
4. Offer contact information for the research team to answer questions.

Enrollment: 200 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults with stage I-II pancreatic ductal adenocarcinoma.
• Underwent curative-intent pancreaticoduodenectomy (conventional or pylorus-preserving).
• Surgery between January 2015 and May 2023.
• Complete clinical and imaging data available.
• Survived at least 6 months postoperatively.

Exclusion criteria

• Preoperative hepatic steatosis
• Incomplete clinical or imaging data
• Death within 6 months after surgery