The Impact of High Intensity Exercise Upon EPC Number and Function in Young Women

University of Leeds

Status: Unknown

Conditions: Exercise Anaphylaxis

Treatments: Behavioral: Sprint interval exercise; Behavioral: Maximal continuous exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT01314573

BIOSCI-10-007

Details and patient eligibility

About

The purpose of the study is to examine the effects of different exercise intensity training programs upon blood vessel function and circulating blood cells involved in blood vessel repair in young women. The long term effects of exercise may be beneficial to cardiovascular health and it is important to understand the training methods that are the most beneficial. In particular we aim to determine if brief maximal exercise improves the function and stiffness of blood vessels and enhance blood vessel repair. Two methods of exercising are being compared, exercise bouts involving intermittent exercise and exercise completed all at once, but at a very high intensity.

Enrollment: 12 estimated patients

Sex: Female

Ages: 18 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Young healthy females
• Between 18-25 years old
• No on medication (this includes contraceptives)

Exclusion criteria

• Medication use (including oral contraceptives)
• Amenorrhoea
• High blood pressure
• Very active (>3 hours per week of organized physical activity)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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12 participants in 2 patient groups

Interval maximal exercise

Experimental group

Description:

Interval exercise involving repeated Wingate tests (30s durations of maximal exercise on a cycle ergometer).

Treatment:

Behavioral: Sprint interval exercise

Continuous maximal exercise

Experimental group

Description:

Continuous exercise of maximal exertion that has been work matched to an initial bout of interval exercise of 4 x 30s of maximal exercise. This exercise is performed on a cycle ergometer.

Treatment:

Behavioral: Maximal continuous exercise