Impact of High Mechanical Index Ultrasound Impulses on Left Ventricular Stroke Volume With Intravenous Microbubbles (MI)

University of Nebraska

Status: Withdrawn

Conditions: Cardiac Disease

Treatments: Diagnostic Test: low MI impulses; Diagnostic Test: high MI impulses

Study type: Interventional

Funder types: Other

Identifiers

NCT05700032

0134-20-FB

Details and patient eligibility

About

This study will investigate whether applying high mechanical index (MI) impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent (UEA) microbubble infusion will result in subclinical improvement in left ventricle systolic function.

Full description

The purpose of this study is to investigate whether applying high MI impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent(UEA) microbubble infusion will result in subclinical improvement in LV systolic function detected by left ventricular outflow tract velocity time integral (LVOT VTI).

Sex: All

Ages: 19+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

age 19 years or older

Exclusion criteria

1. severe aortic valve stenosis
2. pregnant or lactating women
3. atrial fibrillation
4. very poor image quality despite contrast use.
5. unstable cardiac condition such as cardiogenic shock.
6. allergy to UEA
7. presence of right to left or bidirectional shunts.
8. Patients on mechanical circulatory support.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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0 participants in 2 patient groups

high MI

Experimental group

Description:

patients receiving high MI impulses

Treatment:

Diagnostic Test: high MI impulses

low MI

Active Comparator group

Description:

patients receiving low MI impulses

Treatment:

Diagnostic Test: low MI impulses