The Impact of Indocyanine Green-enhanced Fluorescence Imaging on Bowel Transection in Left-sided Colorectal Resection

The University of Hong Kong (HKU)

Status: Unknown

Conditions: Anastomotic Leak

Treatments: Drug: indocyanine green; Device: Fluorescence imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT02669485

UW 16027

Details and patient eligibility

About

The aim of this study was to evaluate the impact of fluorescence imaging on the location of colorectal transection lines based on evaluation of perfusion with indocyanine green, how it's going to affect surgical planning and its possible benefits in reducing anastomotic leakage.

Full description

During surgery, the line of intended bowel transection would be determined by the surgeon. Then the anesthesiologist will administer a bolus of 5mg ICG intravenously (2.5mg/ml, 2ml), followed by 10ml normal saline flush. The perfusion of colon will be assessed via fluorescence angiography. The actual bowel transection, after ICG fluorescence study, would be compared with the intended bowel transection site. The difference in terms of distance and either more proximal or distal is recorded. Then bowel anastomosis is completed in the usual manner.

Enrollment: 30 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• All left-sided colorectal resection involving division of inferior mesenteric artery

Exclusion criteria

• Patients with a history of adverse reaction or known allergy to ICG, iodine, or iodine dyes. Pregnant and/or lactating patients.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

ICG

Experimental group

Description:

Administering indocyanine green during surgery and the use of ICG fluorescence imaging to assess bowel perfusion during surgery

Treatment:

Drug: indocyanine green

Device: Fluorescence imaging