The Impact of Inflammation on Skeletal Muscle Maintenance in Hospitalized Patients (InflaMus)

Bispebjerg Hospital

Status: Invitation-only

Conditions: Geriatric Assessment; Disease Related Malnutrition; High Systemic Inflammation

Treatments: Other: Single leg training

Study type: Interventional

Funder types: Other

Identifiers

NCT06967220

BBH170

Details and patient eligibility

About

The main goal is to elucidate the mechanistic coupling between inflammation and the ability to maintain skeletal muscle through physical exercise while hospitalized. We will investigate protein kinetics in patients who belong to one of three groups 1) high inflammatory state, 2) moderate inflammatory state and 3) low/no inflammation. We will further intervene in group 1 (high inflammatory state) with anti-inflammatory nutrition (primarily green-solution plant-based) to diminish activity in inflammatory pathways. The hypothesis is that inflammation will inhibit protein synthesis in skeletal muscle both in resting muscle and in strength trained skeletal musculature, and that a lowering of the inflammatory status by anti-inflammatory nutrition will enhance the exercise induced formation of new muscle mass. .

Enrollment: 90 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hospitalised at the geriatric department at Bispebjerg Hospital with an expected admission time of minimum 7 days
• Have Disease Related Malnutrition (DRM)
• Able to carry out strength training
• Able to understand the study information, as assessed by the research team

Exclusion criteria

• Current use of anti-inflammatory medication
• Liver failure
• Short bowel syndrome
• Chrohn's or colitis
• Terminally ill

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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90 participants in 1 patient group

Anti-inflammatory diet and supplements

Experimental group

Description:

A sub group of patients with high inflammation will be offered a diet where 50% of the regular hospital diet is switched for diet containing plant based food and nutrients found to lower inflammation

Treatment:

Other: Single leg training