The Impact of Inflammatory Adhesion on the Prognosis of Colon Cancer Patients

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: Colon Cancer

Treatments: Other: This was a retrospective study and no patient intervention was performed.

Study type: Observational

Funder types: Other

Identifiers

NCT06655285

NCC3650

Details and patient eligibility

About

The purpose of this study is to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients.

Full description

In some colon cancer patients, although adhesions between the tumor tissue and surrounding organs are found during surgery, postoperative pathology confirms that the tumor has not directly invaded the adhered organs; instead, the adhesions are caused by tumor-associated inflammation. This condition is defined as tumor-associated inflammatory adhesion.

Currently, the impact of tumor-associated inflammatory adhesion on patient prognosis is still unclear. This study aims to explore the impact of tumor-associated inflammatory adhesion on the prognosis of colon cancer patients through the Surveillance, Epidemiology, and End Results (SEER) and Chinese multi-center databases.

Enrollment: 229 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. The patient was pathologically diagnosed as colon adenocarcinoma by endoscopic biopsy before operation.
2. All patients were considered to have tumors invading adjacent organs during surgery
3. All patients underwent radical surgery.

Exclusion criteria

1. Patients with distant metastasis, recurrent colon cancer and pT4b CRC were excluded.

Trial design

229 participants in 2 patient groups

the U.S. National Cancer Center SEER database

Description:

SEER\*Stat software (version 8.4.3) collected 17 registries cohort data on colon cancer patients between 2010 and 2019.

Treatment:

Other: This was a retrospective study and no patient intervention was performed.

Chinese multi-center database

Description:

Chinese multi-center database includes patients from January 2010 to December 2021 at 3 institutions.

Treatment:

Other: This was a retrospective study and no patient intervention was performed.