The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty

Chimei Medical Center

Status: Completed

Conditions: Postoperative Pain; Ascorbic Acid

Treatments: Drug: Control Rx; Drug: Ascorbic acid 100mg/kg, Maximus 10g

Study type: Interventional

Funder types: Other

Identifiers

NCT05514197

CMMC11104/016

Details and patient eligibility

About

The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.

Enrollment: 73 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Physical status according to American Society of Anesthesiologists (ASA) I-III
2. Patients scheduled for total knee arthroplasty
3. Patients aged ranging from 50 to 80 years old

Exclusion criteria

1. Previous operation on the same knee
2. Allergy or intolerance to one of the study medications
3. Coagulopathy
4. Having lower limbs neuropathy
5. End-organ failure (CKD stage IV or V, NYHA III or IV)
6. BMI > 35
7. Chronic opioid use (>3 months) or drug abuser
8. Difficulty in communication (Impaired mental status)
9. Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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73 participants in 2 patient groups, including a placebo group

Vitamin C arm

Experimental group

Description:

Intravenous loading of 100mg/kg ascorbic acid before induction, Maximus 10g

Treatment:

Drug: Ascorbic acid 100mg/kg, Maximus 10g

Control arm

Placebo Comparator group

Description:

Intravenous loading of the same volume Normal saline as experimental arm

Treatment:

Drug: Control Rx