The Impact of Music on Nociceptive Processing

Mass General Brigham

Status: Completed

Conditions: Catastrophization; Healthy; Pain, Acute; Pain, Chronic; Anxiety Disorders; Anxiety

Treatments: Other: music intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT04087564

2019P000824

Details and patient eligibility

About

The investigators are studying the ways that different music may change pain perception

Full description

In this study, the investigators are comparing healthy individuals to HIV and Fibromyalgia patients. The investigators are measuring the differences in pain processing between subject groups in the presence and absence of different music and distraction conditions. The investigators will be using Quantitative Sensory Testing (QST) in order to induce varying pain conditions on the participants. The investigators will also have participants complete sets of psychosocial questionnaires. Patients with Fibromyalgia tend to have a higher pain sensitivity. Additionally, patients with an HIV diagnosis tend to be prescribed opioid medications. The investigators would like to find out if music can modulate pain, and in turn help reduce the amount of opioid medications those with a chronic pain diagnosis take.

Enrollment: 111 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Healthy volunteers no longer needed for this study (9/9/2021).

Inclusion criteria for Healthy volunteers (N=70) without a diagnosis of neuropathy or chronic pain:

• aged >18 years
• able to speak and understand English
• willingness to undergo psychophysical and psychosocial testing.

Exclusion criteria:

• diagnosed hearing loss
• diagnosis of chronic pain/neuropathy
• history of chronic opioid use (having an opioid prescription >30 days).

Inclusion criteria for Fibromyalgia patients: N=70:

• aged >18 years
• have a diagnosis of fibromyalgia with concurrent chronic pain for > 6 months, and meet the Wolfe et al 2011 research criteria for fibromyalgia
• have an average self-reported pain score of 4/10 or greater
• willing to undergo psychophysical and psychosocial testing
• able to speak and understand English.

Exclusion criteria:

--diagnosed hearing loss.

HIV Patients with chronic pain: N=70

• aged >18- years
• have a diagnosis of HIV infection
• have had chronic pain with onset > 6 months
• have an average self-reported pain score of 4/10 or greater
• willing to undergo psychophysical and psychosocial testing
• able speak and understand English.

Exclusion criteria:

--diagnosed hearing loss.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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111 participants in 1 patient group

music intervention

Experimental group

Description:

Healthy volunteers, and patients diagnosed with HIV or fibromyalgia will complete 4 rounds of QST testing; baseline + 3 music conditions to determine effect of music on pain sensitivity.

Treatment:

Other: music intervention