The Impact of Non-pulsatile Blood Flow on CO2-Reactivity

Medical University of Vienna

Status: Completed

Conditions: Cerebrovascular Circulation

Treatments: Procedure: alteration of PaCO2 level

Study type: Interventional

Funder types: Other

Identifiers

NCT03732651

1018730

Details and patient eligibility

About

The investigators hypothezised that CO2-reactivity of cerebral vessels is affected by systemic non-pulsatile blood flow. Patients undergoing elective cardiac surgery with CPB were enrolled in this prospective case control study. Blood flow velocity in the middle cerebral artery as well as regional cerebral oxygenation was determined during step changes of PaCO2 between 30, 40, and 50 mmHg. Measurements were conducted intraoperatively during non-pulsatile as well as postoperatively after admission to the ICU under pulsatile blood flow.

Enrollment: 32 patients

Sex: All

Ages: 15 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• undergoing elective cardiac surgery with cardiopulmonary bypass

Exclusion criteria

• Carotid artery stenosis (> 50%)
• Neurological pathologies
• COPD with CO2 retention
• Women of childbearing age

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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32 participants in 2 patient groups

non-pulsatile blood flow

Experimental group

Treatment:

Procedure: alteration of PaCO2 level

pulsatile blood flow

Experimental group

Treatment:

Procedure: alteration of PaCO2 level