The Impact of Obesity on Nonsurgical Periodontal Therapy

Federal University of Rio Grande do Sul

Status: Unknown

Conditions: Periodontitis; Periodontal Diseases; Obesity

Treatments: Drug: Placebo; Drug: Metronidazole; Procedure: Scaling and root planning

Study type: Interventional

Funder types: Other

Identifiers

NCT01405365

CNPq-402335/2008-2

Details and patient eligibility

About

The purpose of this study is to investigate the effect that obesity may have on the nonsurgical treatment (with and without the adjunct use of metronidazole) of destructive periodontal diseases (chronic periodontitis).

Full description

Normal weight (BMI 18.5-24.9 kg/m2) and obese (BMI >30 kg/m2) women will be randomly assigned to two nonsurgical periodontal treatments:

1. scaling and root planing + placebo
2. scaling and root planing + metronidazole

Enrollment: 96 estimated patients

Sex: Female

Ages: 35 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal weight or obese (according to BMI)
• nonsmokers or former smokers (3 or more years)
• no systemic diseases that may affect periodontal treatment (diabetes, osteoporosis, steroid use)
• have 10 teeth present
• have at least 2 teeth with probing depth 6+mm and attachment loss 4+mm

Exclusion criteria

• Pregnancy
• Development of diabetes or other conditions that may impair periodontal healing

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

96 participants in 2 patient groups, including a placebo group

Metronidazole

Experimental group

Treatment:

Procedure: Scaling and root planning

Drug: Metronidazole

Placebo

Placebo Comparator group

Treatment:

Procedure: Scaling and root planning

Drug: Placebo