The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males

University School of Physical Education, Krakow, Poland

Status: Enrolling

Conditions: Hypoxia, Altitude

Treatments: Other: Exercise and environmental conditions

Study type: Interventional

Funder types: Other

Identifiers

NCT06204731

SKN/SP/570048/2023

Details and patient eligibility

About

• Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal damage, and mitochondrial energy production rate in young sedentary males.
• Applied objective: Development of practical training guidelines utilizing training in normobaric hypoxia conditions to enhance mechanisms related to oxygen transport, adaptive changes within the immune system, body's antioxidant capacity, gut permeability, substrate utilization efficiency, and mitochondrial function for coaches and athletes.

Enrollment: 50 estimated patients

Sex: Male

Ages: 19 to 29 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• no known metabolic diseases, no contraindications to physical exercise and no history of high altitude sickness stated in interview. A medical examination (including ECG, blood and urine tests) is required.

Exclusion criteria

• changes in diet during the experiment, smoking and abuse of alcohol and/or other stimulants.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 4 patient groups

Control group

No Intervention group

Description:

The control group will not undergo the training program.

LHTL (live high - train low)

Experimental group

Description:

Training performed under normoxic conditions (223m), stay and sleep in normobaric hypoxic conditions (3000m) and thermoneutral conditions (21°C) and constant humidity (40%).

Treatment:

Other: Exercise and environmental conditions

LLTH (live low - train high)

Experimental group

Description:

Training performed under normobaric hypoxia conditions (3000m), stay and sleep in normoxic conditions (223m) and thermoneutral conditions (21°C) and constant humidity (40%). will stay and sleep in normoxic (223m), and train in normobaric hypoxia (3000m)

Treatment:

Other: Exercise and environmental conditions

LLTL (live low - train low)

Experimental group

Description:

Training performed and stay and sleep in normoxic conditions (223m) and thermoneutral conditions (21°C) and constant humidity (40%).

Treatment:

Other: Exercise and environmental conditions