The Impact of Placental Factors on Fetal Intrauterine Growth and in Intrauterine Programming of the Metabolic Syndrome

Clalit Health Services

Status: Unknown

Conditions: Normal Pregnancies

Study type: Observational

Funder types: Other

Identifiers

NCT01883154

loe135673ctil

Details and patient eligibility

About

Genetic and environmental factors are believed to play a major role in intrauterine growth and intrauterine programming. We intend to study genetic factors such as Telomere homeostasis, senescence, genomic instability and the presence of Genomic copy number variations in placental tissue from pregnancies complicated with Intrauterine growth restriction(IUGR), Gestational and pre gestational Diabetes, placentas from IVF pregnancies and from normal pregnancies. We also intend to assess these factors in cord blood and maternal blood.

Full description

Based on the previous data from our group as well as other laboratories, we postulate that there is a correlation between impaired telomere homeostasis, senescence genomic instability and intra-uterine programming in placentas and in fetuses exposed to suboptimal intrauterine conditions such as hypoxia or hyperglycemia. Improved understanding of the mechanisms that produce the genomic changes in IUGR placentas and their influence on later risks of developing the metabolic syndrome should provide basis for future research that might lead into improved outcome of IUGR fetuses.

Enrollment: 160 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• A diagnosis of Intrauterine growth restriction
• A diagnosis of Gestational diabetes
• A diagnosis of pre gestational Diabetes
• IVF pregnancy

Exclusion criteria

• chorioamnionitis
• meconium stained amniotic fluid
• A request of the patient for Cord blood retrieval for preservation

Trial design

160 participants in 4 patient groups

IUGR pregnancies

Description:

Pregnancies complicated with IUGR. Fetal growth beneath the 10th percentile

pregnancies with Gestational Diabetes

Description:

Normal glucose levels before 20 weeks, and positive Oral glucose tolerance test

Pre Gestational Diabetes

Description:

A diagnosis of Diabetes before pregnancy or elevated glucose levels before 20 weeks.

IVF pregnancies