The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants (PFA100)

Ankara University

Status: Completed

Conditions: Patent Ductus Arterioses

Study type: Observational

Funder types: Other

Identifiers

NCT02010879

PDAPFA-100 TRIAL

Details and patient eligibility

About

Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure. Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.

Full description

Patent ductus arterioses is a common problem which involves both pulmonary and cardiac outcomes in preterm infants. Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure.

The investigators aim to investigate the relation between thrombocytopenia and platelet functions in pathogenesis of spontaneous ductal closure. The investigators hypothesize that Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.

Enrollment: 80 estimated patients

Sex: All

Ages: 2 to 7 days old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• gestational age lower than 30 weeks and birth weight lower than 1500 g
• obtained informed consent

Exclusion criteria

• any received medical treatment in first 2 days of life
• death in first 2 days
• patients who received any thrombocyte or fresh frozen plasma suspensions
• any known genetic thrombocyte disorder in the family