The Impact of Preemptive Epidural Analgesia on Acute Postoperative Pain in Pediatric Orthopedic Surgery

Yonsei University

Status: Completed

Conditions: Pediatric Surgical Patients; Preemptive Epidural Analgesia

Treatments: Procedure: 0.2mg/kg of Normal Saline; Procedure: 0.2 ml/kg of 0.2% ropivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02813018

4-2016-0322

Details and patient eligibility

About

Management of postoperative pain is critical in the pediatric patients, however, safe and effective analgesia for pediatric surgical patients remains a challenge. Preemptive analgesia is based on preventing a prolonged change in central nervous system function by blocking afferent input before the surgical stimulation may evoke central sensitization and aggravate amplification and prolongation of postoperative pain. However, the clinical efficacy of preemptive analgesia is still controversial. In this study, the investigators aim to assess the impact of preemptive epidural analgesia on postoperative pain in pediatric patients for corrective osteotomy of the lower extremities expecting severe postoperative pain.

Enrollment: 50 patients

Sex: All

Ages: 3 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pediatric patients (3-12 years of age) scheduled for corrective osteotomy of the lower extremities
• ASA class I and II

Exclusion criteria

• Coagulopathy
• Neurological disease
• Allergy to local anesthetics or contraindication to use of ropivacaine
• Infection at the site of epidural catheter insertion

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

preemptive group

Experimental group

Description:

Group who will be received ropivacaine bolus and continous infusion 5 minutes before skin incision.

Treatment:

Procedure: 0.2 ml/kg of 0.2% ropivacaine

saline group

Placebo Comparator group

Description:

Group who will be received saline bolus and continous infusion 5 minutes before skin incision

Treatment:

Procedure: 0.2mg/kg of Normal Saline