The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome

Uppsala University

Status: Completed

Conditions: Corona Virus Infection; ARDS, Human; Sepsis

Treatments: Other: No intervention, observational study

Study type: Observational

Funder types: Other

Identifiers

NCT04542538

U1111-1257-2830

Details and patient eligibility

About

The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring intensive care unit (ICU) -care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish adult respiratory distress syndrome (ARDS) -cohort.

Full description

The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring ICU-care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish ARDS-cohort.

Enrollment: 9,905 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

° Individual registered in the Swedish intensive care registry (SIR) with COVID-19 Before 27 May 2020.

or

• Individual registered in the SIR with Severe sepsis or septic chock 2011-2016. or
• Individual registered in the SIR with ARDS 2011-2016.

Exclusion criteria

• Age below 18 years
• Individual registered in the Swedish intensive care registry without a personal identification number

Trial design

9,905 participants in 3 patient groups

COVID-19 critical care patients

Description:

All patients who have received intensive care with COVID-19 in Sweden until May 27, 2020. Patients are identified in the Swedish Intensive care registry, to which all Swedish intensive care units (ICU) are reporting all intensive care patients.

Treatment:

Other: No intervention, observational study

Sepsis critical care patients

Description:

All patients who have received intensive care with severe sepsis or septic shock in Sweden between 2011 and 2016. Patients are identified in the Swedish Intensive care registry, to which all Swedish intensive care units (ICU) are reporting all intensive care patients.

Treatment:

Other: No intervention, observational study

ARDS critical care patients

Description:

All patients who have received intensive care with ARDS in Sweden between 2011 and 2016. Patients are identified in the Swedish Intensive care registry, to which all Swedish intensive care units (ICU) are reporting all intensive care patients.

Treatment:

Other: No intervention, observational study