The Impact of Protein Intake on Protein Metabolism During Intensified Training

University of Toronto

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: High; Other: Controlled-diet; Dietary Supplement: Moderate; Dietary Supplement: Normal

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02801344

PFE

Details and patient eligibility

About

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

Our recent study using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 30% higher than the recommended protein intake.

The present study will investigate the impact of protein sufficiency on protein metabolism and performance during intensified training periods as a means to further our understanding of the nutritional requirements for the endurance athlete.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy, male, endurance-trained participants who have run regularly more than 45 km or 4.5 hours/week
• Participants who are categorized at least "very good" based on a study by Shvartz & Reibold [40], in which peak rate of oxygen consumption(VO2 Peak) is used as an index. (i.e. the participants whose VO2peak is ≥57 ml/kg/min (18-24 y), ≥54 ml/kg/min (25-29 y), ≥52 ml/kg/min (30-34 y), ≥49 ml/kg/min (35-39 y), ≥47 ml/kg/min (40-44 y), ≥44 ml/kg/min (45-50 y) according to his age,
• Participants who can cover 10 km in less than 60 min after the VO2peak test and 5 km Time trial on session 2.
• Participants will be 18-50 years old.
• Participants are willing to abide by the compliance rules of this study

Exclusion criteria

• Inability to meet health and physical activity guidelines according to the The Physical Activity Readiness Questionnaire for everyone.
• Female
• Inability to adhere to any of the compliance rules judged by principal investigator or medical doctor
• Regular tobacco use
• Illicit drug use (e.g. growth hormone, testosterone, etc.)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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12 participants in 3 patient groups

Normal protein intake

Experimental group

Description:

participants will receive the controlled-diet containing 0.8 g protein /kg/day and the test drink containing 0.14 g protein/kg/d.

Treatment:

Other: Controlled-diet

Dietary Supplement: Normal

Moderate protein intake

Experimental group

Description:

participants will receive the controlled-diet containing 1.20 g protein /kg/day and the test drink containing 0.40 g protein/kg/d.

Treatment:

Other: Controlled-diet

Dietary Supplement: Moderate

High protein intake

Experimental group

Description:

participants will receive the controlled-diet containing 1.83 g protein /kg/day and the test drink containing 1.03 g protein/kg/d.

Treatment:

Other: Controlled-diet

Dietary Supplement: High