The Impact of Qualia Gluthathione+ on Blood Glutathione Levels

Qualia Life Sciences

Status: Completed

Conditions: Effects of Qualia Glutathione+ on Blood Glutathione Levels; Glutathione

Treatments: Dietary Supplement: Qualia Glutathione+ version 2; Dietary Supplement: Placebo; Dietary Supplement: Qualia Glutathione+ version 1

Study type: Interventional

Funder types: Industry

Identifiers

NCT07221955

QLS-019

Details and patient eligibility

About

This is a double-blind, placebo-controlled, parallel-group, triple-armed, study evaluating the effects of two distinct Qualia Glutathione+ formulations on Whole Blood Glutathione levels in the blood of healthy adults aged 45-75 years. Approximately 18 participants will be assigned to one of three study arms: Qualia Glutathione+ version 1, Qualia Glutathione+ version 2, or placebo. Each participant will take two or three capsules of their assigned product once daily in the morning, with or without food, over a 20-day period. The primary outcome is the change in blood glutathione levels, assessed via in lab blood collection at baseline and study completion. Secondary endpoints include questionnaires measuring health-related quality of life, fatigue, and cognitive functioning (PROMIS Global Health-10, PROMIS Short Form v1.0 - Fatigue 10a, PROMIS Cognitive Function - Short Form 8a), evaluation of safety and tolerability, and an Overall Experience Questionnaire (Appendices 1, 4-7). All assessments, including electronic questionnaires, are completed remotely without in-person visits.

Full description

Note on allocation (added September 2026): Participants were assigned to study arms by systematic allocation rather than by random allocation. Earlier versions of this record described the design as randomized. The Allocation field and the design descriptions were corrected to Non-Randomized to reflect the method actually used. No other aspect of the study design, conduct, or analysis changed.

Enrollment: 56 patients

Sex: All

Ages: 45 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Provide voluntary, written, informed consent to participate in the study
• Agree to provide a valid cell phone number and are willing to receive communications through text
• Can read and write English
• Willing to not begin taking any new supplements during the study and continue taking any supplements they are currently using regularly
• Willing to complete questionnaires, records, and diaries associated with the study.
• Healthy male and female participants aged 45-75 years
• Willing to go to a local blood draw location for a Whole Blood Total Glutathione measurement (baseline and Day 20)
• Willing to avoid starting new or stopping any existing dietary supplements throughout the study

Exclusion criteria

• Women who are pregnant, breastfeeding, or planning to become pregnant during the trial
• Known food intolerances/allergy to any ingredients in the product
• Having any of the following conditions: Psychiatric conditions, neurologic disorders, endocrine disorders, cancer
• Having had a significant cardiovascular event in the past 6 months
• Taking MAO inhibitors, SSRIs, or any other psychiatric or neurological medicines
• On immunosuppressive therapy
• Adults lacking capacity to consent
• Active Smokers
• Diagnosed Diabetics

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

56 participants in 3 patient groups, including a placebo group

Qualia Glutathione+ version 1

Active Comparator group

Description:

Qualia Glutathione+ version 1 manufactured by Qualia Life Sciences

Treatment:

Dietary Supplement: Qualia Glutathione+ version 1

Qualia Glutathione+ version 2

Active Comparator group

Description:

Qualia Glutathione+ version 2 manufactured by Qualia Life Sciences

Treatment:

Dietary Supplement: Qualia Glutathione+ version 2

Placebo

Placebo Comparator group

Description:

Rice flour placebo

Treatment:

Dietary Supplement: Placebo