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The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults

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Old Dominion University

Status

Enrolling

Conditions

Vascular Function
Exercise
Glucose Intolerance

Treatments

Other: removal of exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT05468255
AGEGLYFMD

Details and patient eligibility

About

The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

Enrollment

40 estimated patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. 55 years and older, 18-40 years old
  2. Healthy, physically active, performing at least 90 min/week of physical activity
  3. Free of physical limitations that may interfere with alterations in daily physical activity levels

Exclusion criteria

  1. Physician diagnosed HIV, hepatitis, or tuberculosis.
  2. Body weight change of greater than 5% within the previous 2 months
  3. Smoking within the previous 2 months.
  4. Taking medications that alter blood glucose levels

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

40 participants in 2 patient groups

Metabolic
Experimental group
Description:
Metabolic: Participants will have their blood glucose levels measured via continuous glucose monitoring for 3 days while participating in their normal exercise routines (EX). Participants will also have their blood glucose levels measured for 3 days while not exercising (NOEX), following immediately by 3 days of a return to normal activity(REX). Participants will be randomized to participate in the EX or NOEX/REX phases first. The EX and NOEX/REX phases will be separated by at least 1 week
Treatment:
Other: removal of exercise
Vascular
Experimental group
Description:
Vascular: Participants will have their blood vessel health measured while performing their normal exercise routines (EX) and while undergoing 1, 3, 5 days of no exercise (NOEX) followed immediately by 1 and 3 days of return to exercise (REX).
Treatment:
Other: removal of exercise

Trial contacts and locations

1

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Central trial contact

Leryn Reynolds

Data sourced from clinicaltrials.gov

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