The Impact of Routine Measurement of Cardiac Troponin (hsTnT) on Outcome in Elderly Patients Undergoing Major Surgery

Universitair Ziekenhuis Brussel

Status: Terminated

Conditions: Mortality; Surgery--Complications; Elderly

Treatments: Diagnostic Test: diastolic function assessment; Diagnostic Test: level of cardiac troponin

Study type: Observational

Funder types: Other

Identifiers

NCT03605134

Troponin

Details and patient eligibility

About

To document levels of cardiac troponin hsTnT in patients above 75y undergoing high risk surgery and the relationship between elevated levels and outcome in terms of hospital stay and 30 day mortality.

Full description

Elevated troponin (Tn) hsTnT levels occur as a result of myocardial damage and are used in the diagnosis of myocardial infarction (MI). However, there are multiple different causes that also result in abnormal Tn levels, such as direct myocardial-cell injury, impaired renal excretion and sepsis. Because of this, elevated Tn level is a common finding in hospitalized patients.

Several studies on patients admitted to the intensive care unit (ICU) without MI show that Tn elevation is a mortality risk factor and an independent predictor of hospital mortality.

Up till now it is not yet known if the routine measurement of Tn in elderly patients undergoing surgery can significantly improve their outcome and that is the primary aim of this study. In addition, it is not known what the impact could be if a diastolic function assessment could be performed peri-operatively.

This study will examine the correlation between elevated Tn levels in elderly patients undergoing major surgery and their short-term outcome (in-hospital). Before and immediately after surgery, diastolic function will be assessed by means of transthoracic echocardiography (TTE).

Enrollment: 63 patients

Sex: All

Ages: 75 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients ≥75 y undergoing elective and major surgery till we have collected an entire dataset of 100 patients.
• Only those patients will be included who are planned for elective and major surgery.

Exclusion criteria

• Patients under the age of 75
• Intraoperative mortality
• Eye surgery
• Cardiac or thoracic surgery
• Patients undergoing surgery which is not withheld as major surgery
• For patients undergoing multiple surgeries for the same indication and during the same hospitalization, only the first surgery will be included

Trial design

63 participants in 1 patient group

study group

Description:

level of cardiac troponin and diastolic function assessment by means of transthoracic echocardiography

Treatment:

Diagnostic Test: level of cardiac troponin

Diagnostic Test: diastolic function assessment