The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy

Ege University

Status: Completed

Conditions: Ectopic Pregnancy; Infertility

Treatments: Procedure: salpingectomy; Drug: Methotrexate

Study type: Interventional

Funder types: Other

Identifiers

NCT02714998

2013-TIP-043

Details and patient eligibility

About

The investigators aimed to investigate the effects of salpingectomy and Methotrexate administration on ovarian reserve in ectopic pregnancy.

Full description

In this study, the effects of unilateral laparoscopic salpingectomy and single dose of systemic Methotrexate administration on ovarian reserve in patients diagnosed with ectopic pregnancy were investigated.

Enrollment: 131 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ectopic pregnancy diagnosis

Exclusion criteria

• history of endometriosis, ovarian surgery, systemic chemotherapy, ART treatment.
• patients treated with multiple doses of methotrexate or different surgical procedure (salpingostomy, milking)

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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131 participants in 3 patient groups

Methotrexate only

Active Comparator group

Description:

Single dose of systemic Methotrexate administered to 55 patients.

Treatment:

Drug: Methotrexate

Salpingectomy only group

Active Comparator group

Description:

Laparoscopic unilateral salpingectomy performed to 61 patients.

Treatment:

Procedure: salpingectomy

Salpingectomy following Methotrexate

Active Comparator group

Description:

15 patients underwent laparoscopic unilateral salpingectomy following unsuccessful single dose of methotrexate administration.

Treatment:

Procedure: salpingectomy

Drug: Methotrexate