The Impact of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation in Healthy Adults

Jilin University

Status: Completed

Conditions: Remote Ischemic Conditioning

Treatments: Procedure: Intravenous blood collection; Device: dCA measurement; Device: BB-RIC-D1/LAPUL Medical Devices Co, Ltd, China

Study type: Interventional

Funder types: Other

Identifiers

NCT04899362

SRIC-CA

Details and patient eligibility

About

The purpose of this study is to determine the impact of serial remote ischemic conditioning on dynamic cerebral autoregulation and related hematology indexes in healthy adults.

Full description

Remote ischemic conditioning(RIC) is the phenomenon whereby brief cycles of ischemia and reperfusion, applied to a distant organ, provide protection to the target organ. Dynamic cerebral autoregulation(dCA), a mechanism to maintain the cerebral blood flow, has been proved to be critical for the occurrence,development and prognosis of ischemic neurovascular disease. In this study, we hypothesis that RIC provides neuro-protection by means of improving dCA.

Enrollment: 36 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age from 18 to 50,both genders
• willing to participate in follow-up visits

Exclusion criteria

• current or having a history of chronic physical diseases or mental diseases
• suffering from infectious diseases in late one month
• pregnant and lactating women#
• smoking or drinking#
• inability to cooperate sufficiently to complete the dCA examination

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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36 participants in 1 patient group

RIC group

Experimental group

Description:

RIC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take 14 RIC intervention, blood collection and 10 dCA measurements.

Treatment:

Device: dCA measurement

Device: BB-RIC-D1/LAPUL Medical Devices Co, Ltd, China

Procedure: Intravenous blood collection