The Impact of Sodium and Fructose on Blood Pressure and Inflammation

University of Delaware

Status: Completed

Conditions: Inflammation; Blood Pressure

Treatments: Dietary Supplement: Recommended sodium and low fructose diet; Dietary Supplement: High sodium and high fructose diet; Dietary Supplement: High sodium and low fructose diet

Study type: Interventional

Funder types: Other

Identifiers

NCT04994418

1617405-2

Details and patient eligibility

About

The goal of this study is to determine the impact of dietary sodium and fructose on blood pressure and inflammation in young healthy adults.

Full description

Excess dietary salt is associated with an increased risk of cardiovascular diseases. Some healthy adults have been determined to be more sensitive to dietary salt than others, which can result in a 10% or more increase of blood pressure. The mechanisms underlying salt sensitivity of blood pressure are not fully understood. Previous research has suggested excess intake of added sugars, especially fructose, can increase salt sensitivity of blood pressure. Chronic elevated consumption of salt and fructose independently have been shown to have damaging effects on the body, however, the combination of both salt and fructose has not been fully studied in humans. The purpose of this research study is to determine if increased dietary fructose consumption will stimulate salt-sensitive hypertension and induce proinflammatory cytokines through activation of the immune system. Understanding how the body regulates blood pressure during times of elevated salt and fructose is important for determining cardiovascular risk in a population with normal blood pressure.

Enrollment: 91 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• normal blood pressure
• males, females, minorities

Exclusion criteria

• high blood pressure
• body mass index (BMI) of > 30 kg/m2
• smokers or nicotine users
• pregnancy

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

91 participants in 3 patient groups

Arm 1. Recommended sodium and low fructose diet

Experimental group

Description:

7 day consumption of low fructose drink (20g) and recommended sodium (2300mg) from whole food while consuming placebo from pills

Treatment:

Dietary Supplement: High sodium and low fructose diet

Dietary Supplement: High sodium and high fructose diet

Arm 2. High sodium and low fructose diet

Experimental group

Description:

7 day consumption of low fructose drink (20g) and recommended sodium (2300 mg) from whole food while consuming high sodium from pills (3400 mg)

Treatment:

Dietary Supplement: High sodium and high fructose diet

Dietary Supplement: Recommended sodium and low fructose diet

Arm 3. High sodium and high fructose diet

Experimental group

Description:

7 day consumption of high fructose drink (200g) and recommended sodium (2300 mg)from whole food while consuming high sodium pills from pills (3400 mg)

Treatment:

Dietary Supplement: High sodium and low fructose diet

Dietary Supplement: Recommended sodium and low fructose diet