The Impact of Soft Contact Lenses on the Corneal Neuromediators and Optical Quality in High Myopia Prior to SMILE

yuhao shao

Status: Enrolling

Conditions: Contact Lens Complication

Treatments: Other: This study does not involve any interventions

Study type: Observational

Funder types: Other

Identifiers

NCT06650306

SHSY-IEC-5.0/23K74/P01

Details and patient eligibility

About

To investigate the influence of Neuromediators expression in corneal stromal lenticules and corneal injury repair after small incision extraction

Full description

This study included 160 eyes from high myopia patients who underwent Small Incision Lenticule Extraction. Patients were devided into three groups based on duration of wearing SCLs: > 10 years group, ≤ 10 years group, and NW group (not SCLs). Corneal higher-order aberrations and densitometry were evaluated using a Pentacam system. Neuromediator levels in corneal stromal lenticules were analyzed using ELISA and immunofluorescence

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age ≥ 18 years with stable refraction for at least two years;
• spherical equivalent (SE) < -6.00 D;
• corrected distance visual acuity of 20/20 or better;
• no history of using rigid gas permeable lenses or orthokeratology (OK) lenses prior to examination

Exclusion criteria

• a history of moderate to severe dry eye as well as any ocular or systemic disease that would contraindicate laser refractive surgery.

Trial design

80 participants in 3 patient groups

SCLs >10 years

Description:

high myopia patients who wear SCL more than 10 years before Small Incision Lenticule Extraction

Treatment:

Other: This study does not involve any interventions

SCLs ≤10 years

Description:

high myopia patients who wear SCL for 10 years or less before Small Incision Lenticule Extraction

Treatment:

Other: This study does not involve any interventions

NW

Description:

high myopia patients who have not worn SCLs before Small Incision Lenticule Extraction

Treatment:

Other: This study does not involve any interventions